Unfractioned heparin available in our unit is 5000 IU/mL
Load with 75 IU per Kg, over 10 minutes,
And maintain at 28 IU per kg per hour, keeping aPTT between 60 to 85 seconds
UFH is 5000 IU per mL.
So we ll take 20 units in insulin syringe,
It will give us 1000 IU of UFH.
Next, we will dilute this 0.2mL in a 10 cc syringe. It will give us 1000 IU in 10 cc (or 100 IU per 1cc)
Next,
We prepare the infusion of UFH in normal saline in syringe or microburette and
When we are either giving infusion via syringe pump or using infusion pump with burette, in both cases we discard the fluid in tubing (15mL) from syringe or from chamber of burette, it will discard the 15 mL fluid that may not have heparin and will also prime the tubing with heparin, so that right from start of infusion patients
gets to have heparin therapy with the intended dose.
If the patient has poor perfusion, LMWH has renal clearance while UFH does not use renal excretion pathway, hence its recommended in such cases with poor perfusion or renal failure.